What happens if we take Paracetamol with Ibuprofen. Specialists are drawing an alarm signal
Researchers have found that the mixture of ibuprofen and paracetamol can help supermicrobes resist antibiotics, leaving people exposed to infections increasingly difficult to treat.
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Common pills, often taken for headaches, fever and daily pain, would trigger dangerous bacterial mutations when used with Ciprofloxacin antibiotic, commonly used to treat urinary tract, according to The Sun.
Australian researchers have tested drugs on E. coli and found that they have made the bacteria not only resistant to Ciprofloxacin, but also to several other antibiotics that usually eliminate it.
This process, known as antibiotic resistance (AMR), occurs when bacteria, viruses, fungi or parasites evolve into supermarkets that can withstand drugs designed.
Professor Rietie Venter, an expert in microbiology at the University of South Australia and the main author of the study, said that the present study reminds us that “We must carefully analyze the risks of using more drugs. ”
“Antibiotic resistance is not just about antibiotics. This study is a clear reminder that we must carefully analyze the risks of using more drugs – especially in the elderly care, where residents often receive combinations of long -term treatments. This does not mean that we should stop using these drugs. But we must be more attentive to how they interact with antibiotics, and that includes the analysis beyond the combinations of two drugs ”, he explained.
For the study, published in the Journal of Antimicrobials and Resistance, scientists have analyzed the effects of nine types of drugs used in elderly homes together with ciprofloxacin, including sleeping pills and decongestants.
In laboratory tests, ibuprofen and paracetamol have proven to be the most problematic, triggering most genetic mutations and allowing bacteria to develop faster and become extremely resistant, explained Professor Rietie.
“It is worrying that bacteria have not only become resistant to the Ciprofloxacin antibiotic, but an increase in resistance and multiple antibiotics from different classes has been observed.
I also discovered the genetic mechanisms behind this resistance, ibuprofen and paracetamol activating the defense mechanisms of bacteria, which expel antibiotics and make them less efficient ”he added.
The World Health Organization (WHO) estimates that drug -resistant bacteria have been directly responsible for 1.27 million deaths in 2019 and associated with almost 5 million.
Meanwhile, an analysis of the Global Research on Antimicrobial Resistance (Gram) Project suggests that over 39 million people worldwide could die because of antibiotic resistant infections.
The researchers predicted, in 2024, that the number of deaths caused by AMR among people over 70 will double by 2050.
